Next generation sequencing in cancer research and clinical application
1 Washington University, 63130, St. Louis, MO, USA
2 Center for Quantitative Sciences, Vanderbilt University School of Medicine, 37232, Nashville, TN, USA
3 Department of Biomedical Informatics, Vanderbilt University School of Medicine, 37232, Nashville, TN, USA
Biological Procedures Online 2013, 15:4 doi:10.1186/1480-9222-15-4Published: 13 February 2013
The wide application of next-generation sequencing (NGS), mainly through whole genome, exome and transcriptome sequencing, provides a high-resolution and global view of the cancer genome. Coupled with powerful bioinformatics tools, NGS promises to revolutionize cancer research, diagnosis and therapy. In this paper, we review the recent advances in NGS-based cancer genomic research as well as clinical application, summarize the current integrative oncogenomic projects, resources and computational algorithms, and discuss the challenge and future directions in the research and clinical application of cancer genomic sequencing.